Post-Exposure Prophylaxis Protocol

If a person that has not been vaccinated is exposed to a rabid animal, the following is required for post exposure prophylaxis:

  • Human Rabies Immune-Globulin (HRIG) on day 0, plus a series of Human Rabies Vaccines (HRV) on days 0, 3, 7, and 14 (immunocompromised patients should receive a 5th dose on day 28 and subsequent titer check).
  • Persons with previous rabies vaccination [i.e., those who completed the series of the three vaccine pre exposure prophylaxis or the series of four/five vaccines and Human Rabies Immune Globulin post exposure prophylaxis (using Human Diploid Cell Vaccine, Rabies Vaccine Adsorbed, or Purified Chick Embryo Vaccines)], should receive two doses of rabies vaccine on days 0 and 3. The person does not need Human Rabies Immune Globulin.

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Other recommended measures include: